An Aesop Fable (see The Tortoise and the Hare # 455 for more information on Aesop’s Fables)
There's no place like home!
Compare and contrast town vs. country and their different lifestyles.
Open a discussion about customs, cultural differences and getting out of one’s comfort zone.
This story lends itself to making a comparison chart between the two mice.  
If age appropriate use a Venn Diagram.